Gelatin?Lysozyme Nanofibrils Electrospun Patches with Improved Mechanical, Antioxidant, and Bioresorbability Properties for Myocardial Regeneration Applications

Biopolymeric patches show enormous potential for the regeneration of infarcted myocardium tissues. However, most them usually lack appropriate mechanical performance, stability in water, and important functionalities; instance, antioxidant activity. Protein nanofibrils, such as lysozyme nanofibrils (LNFs), are biocompatible nanostructures with excellent water insolubility, activity exploited to fabricate materials different biomedical applications. In this study, LNFs used produce gelatin electrospun nanocomposite cardiac improved properties. The addition enhance their properties, increasing Young's modulus from 3 6 MPa, wet state, which agrees requirements myocardial contractility. Additionally, it is observed an increment 80%, by adding only 5% (w/w) LNFs, bioresorbability rate shortened 30–35 d, compared 45 d gelatin-only patches, while maintaining morphology, biocompatibility toward cardiomyoblasts fibroblasts. Furthermore, 15% a model drug burst released preserved 21 d. Overall, these results demonstrate that have great functional reinforcements biopolymeric tissue regeneration.